The following research lines are being conducted in the laboratory:
1) Recognition of intracellular pathogens by cytoplasmic pattern recognition receptors and their importance in host resistance
(Reconhecimento de patógenos intracelulares por receptores citoplasmáticos e sua importância no controle da infecção microbiana)
2) Molecular pathogenesis and subversion of host responses in infections by intracellular pathogens
(Patogênese molecular e subversão das respostas do hospedeiro em infecções por patógenos intracelulares)
3) Determination of mammalian genes and loci responsible for resistance against an infection by intracellular pathogens
(Determinação de genes e loci de mamíferos responsáveis pela resistência contra a infecção por patógenos intracelulares)
4) Use of high-content screening to identify compounds with leishmanicidal activity in Leishmania-infected macrophages
(Utilização de varredura por high-content para identificar compostos com atividade leishmanicida em macrófagos infectados por Leishmania)
5) Development of genome-wide, high-throughput screening (using CRISPR/CAS9) to identify novel pathways involved in host response to intracellular pathogens.
(Desenvolvimento de genome-wide, high-throughput screening (por CRISPR/CAS9) para identificar novas vias de sinalização envolvidas na resposta do hospedeiro contra patógenos intracelulares)
6) Evaluate activation of innate immune responses in clinical material from patients infected with Leishmania (L. braziliensis, L. infantum) or virus (SARS-CoV-2, Infuenza, Mayaro and Chikungunya)